In contemporary trichological practice, the effective and safe management of androgenetic alopecia, as well as the maintenance of longterm remission, remains a pressing issue for dermatovenereologists. Despite well-established treatment protocols incorporating both pharmacological and injectable methods, the overall satisfaction with therapy among both patients and practitioners is not always optimal.

Low patient compliance is commonly observed due to the prolonged therapy duration, further compounded by concerns regarding disease exacerbation upon discontinuation of treatment. Therefore, the implementation of combined treatment tactics has become particularly relevant, as such approaches can achieve clinically significant synergistic effects while also reducing the total duration of therapy.

This article presents a case study concerning the treatment of female-pattern androgenetic alopecia using a combined protocol that includes photodynamic therapy, RF-microneedling and topical application of exosomes derived from Damask rose stem cells. The pathophysiological mechanisms underlying these interventions are discussed, as well as the potential integration of these methods into standard care algorithms.

Nadezhda Salamashenko has a dual specialization as a dermatologist and cosmetologist, serving as Chief Physician at INSKIN LLC St. Petersburg with more than 20 years of clinical practice. She regularly participates in International scientific and practical congress as a speaker. She is also a clinical trainer in injectable, laser and regenerative treatment methods in dermatology.