Background: Colorectal Cancer (CRC) is present in the colon and rectum (large intestine), and the disease is expanding worldwide, CRC ranks as the third most common cancer worldwide and second after breast cancer locally. It is strongly linked to bad lifestyle factors. The study of the immunosuppressive status of CRC patients through screening and laboratory tests is crucial and is now one of the priorities. This study aims to assess the immune response to colorectal cancer by measuring the serum concentrations of IL-35 and IL-10. 

Methods: The study has been approved by the College of Medical Al-Iraqia University. One hundred male and female patients from the medical city and Al-kadhimiya hospitals suffering from problems in the colon and rectum participated in this study, they donated 5 ml of their blood, which lasted for five months (from Aug.2023 until Jun. 2024). The participants were divided into two groups: the 1st one contained CRC patients, while the 2nd contained Colorectal problems other than CRC.ELISA tests for IL-35 and IL-10 serum level estimation were used. Demographic data such as age, gender, address, and medical history were collected from the study participants. 

Results: The serum levels of IL-35 and IL-10 in CRC patients showed significant differences (P<0.05) when compared with the control group. 

Conclusion: IL-35 and IL-10 significantly appeared as indicators for the immune suppressive status of CRC patients.

Prof.Dr. Ahmed Rushdi Abdullah is a distinguished academic and medical professional, currently serving as the Head of the microbiology department and a professor of immunology, specializing in cancer immunology, at Al-Iraqia University’s College of Medicine. He is also the Head of the Continuing Education Unit (CEU) and a member of the Medical College Board. He is an esteemed member of the Iraqi Board for Medical Specializations/Clinical Radiation Oncology Board and has earned recognition as a fellow at King’s College London. He represents King’s College London in Iraq and is an active member of several prestigious professional organizations, including the British Society for Immunology, the American Association for Cancer Research (AACR), and the French Society for Stem Cell Research. In addition to his academic and clinical roles, he serves as a Senior Advisor for UNIHOUSE, The British Education Point, contributing his expertise to the advancement of education and research.