Introduction: Cancer in Chile is a public health problem. Currently, it causes more than 28,000 deaths in Chile, constituting the second cause of death in the country. Among the great advances in the process of diagnosis and treatment of cancer, there is precision medicine. However, given the uneven national reality and the slow progress towards NGS, we must opt ​​for reliable, rapid and lower cost techniques of implementation, such as the rapid Idylla PCR and devise strategies that bring NGS closer to feasibility. To this end, a series of recommendations are proposed.

Methods: A critical reading of a selection of scientific articles regarding the epidemiology of cancer in Chile is carried out; from the national and international cancer guidelines, with emphasis on lung, breast and colorectal cancer, and the sections on molecular pathology tests and; from documents related to financing of targeted therapies. Suggestions were made from the reading and reviewed by a panel of specialists.

Results: A series of recommendations that propose the complementary and optimized use of Idylla with NGS and contribute to the development of precision medicine.

Discussion: In Chile, there is limited access to molecular studies and targeted therapies. Despite the great importance of optimizing available resources, it is essential to invest and work on the development of strategies that achieve advances in precision medicine.

Conclusions: Idylla facilitates access to precision medicine in a cost-effective manner, covering multiple real-world needs, being necessary and perfectly complementary to NGS. It is necessary to increase access to cutting-edge therapies to maximize the value of precision diagnosis.