Since there are currently no interesting treatment options for men with early-stage Dupuytren's disease, new, safe and effective treatment methods are required to improve the quality of life of such patients. Over the past decade, sugar water 5% injections have received increasing attention from clinicians worldwide. Glucopuncture is a new term to describe Glucose 5% or dextrose 5% injections into dermis, fascia, muscles, tendons and ligaments. In this clinical case, a 75-year-old man was treated with Glucopuncture for a painless nodule on the right hand. A marked reduction in hardness and size of the nodule was observed after six sessions. Establishing a case series with imaging before and after treatment could be a first step to further illustrate the effects of this novel injection technique. At this point, the method was not effective for younger patients. Randomized controlled trials (RCTs) with sufficient sample size are needed to establish the value of Glucopuncture for painless nodules in Dupuytren's disease. 

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