Sepsis-induced cardiomyopathy is a reversible cause of myocardial dysfunction, characterized by impairments of myocardial structure and function generated by inflammatory cytokines and mitochondrial dysfunction. Approximately, up to 50% of patients with severe sepsis and septic shock suffer from some form of systolic alteration of left ventricular function. A 37-year-old female who presented abdominal pain with abdominal distension that presented with septic shock to the emergency unit. In the laboratory tests they showed an infectious process. An abdominal computed tomography scan was performed, that revealed pelvic collection at the level of the right iliac fossa. Transthoracic echocardiogram showed generalized hypokinesis of the left ventricle, with 25% reduced left ventricular ejection fraction. Management with vasopressors and inotropes, antibiotic therapy, invasive mechanical ventilation, and goal-guided fluid resuscitation was started, despite all the patient’s medical effort with a fatal outcome.